How Long Do The Side Effects of Wegovy (semaglutide) Last?

Patients with a body mass index (BMI) of over 30 or those with a BMI of 27 and weight-related health issues can benefit from Wegovy, an injectable drug that helps patients lose weight. It does have adverse effects, though, just like any other medication. However, what is the duration of Wegovy’s adverse effects?

Continue reading to find out more about the most typical Wegovy side effects, their duration, and how to deal with them.

 

What Is Wegovy?

Adults and children aged 12 and above who are obese or overweight who suffer from weight-related conditions including high blood pressure or high cholesterol are approved and can use the weight-loss drug Wegovy (semaglutide).

Once a week, Wegovy is injected beneath the skin in your stomach, thighs, or upper arms. Every week, you give the injection on the same day, with or without meals.

We will teach you how to give the injection at home whenever it is most convenient for you when you come see us.

Because a very tiny needle is used to deliver the injection, most patients report no discomfort.
Semaglutide, the active component of Wegovy, is also included in Ozempic, a diabetic treatment drug. The hormone that regulates hunger and food cravings is mimicked by semaglutide.

In March 2024, the FDA approved Wegovy for use in individuals with cardiovascular disease (heart, blood vessel disease) who are overweight or obese in order to help reduce their risk of heart attack, stroke, and death from cardiovascular disease.

 

How Does Wegovy Work for Weight Loss?

Semaglutide, commonly known as a GLP-1 (glucagon-like peptide-1 receptor agonist), is the active ingredient in Wegovy. The GLP-1 hormone, which is normally released into the digestive tract when we eat, is mimicked by Wegovy.

The GLP-1 hormone prolongs feelings of fullness by delaying the emptying of the stomach. Additionally, it lessens cravings in between meals by influencing the brain’s reward system. Additionally, Wegovy supports your ongoing weight reduction efforts by safely lowering your set point.

After three clinical studies shown that semaglutide considerably outperformed other medications and a placebo in weight reduction, the Food and Drug Administration approved Wegovy as a weight loss therapy in 2021.

After 16 months, patients who received Wegovy dropped an average of 15-20%of their body weight.

 

When Do You Begin to Feel the Side Effects of Wegovy?

As soon as you take the first dosage of Wegovy or a few weeks later, you may experience adverse effects. They often appear at the beginning of treatment or after a dose increase when individuals take Wegovy as prescribed. You should always speak with your provider before changing your dosage or increasing your current one if you’re having negative affects.

Because doctors begin with a lower dose of Wegovy and raise it gradually over a few weeks to give the body time to adapt to the weight loss drug, some people might not experience the adverse effects of the medicine right away.

 

How Long Do Wegovy Side Effects Last?

The majority of Wegovy’s adverse effects are mild to moderate and typically last a few days to weeks. In the days that follow an increase in your weekly injectable dosage, symptoms may worsen.

In clinical trials, Less than 7% of individuals thought their side effects were serious enough to force them to quit taking Wegovy. When the medicine is stopped entirely, the adverse effects usually disappear.

 

What Are the Common Side Effects of Wegovy?

Wegovy may lessen appetite and encourage weight reduction in part by delaying the emptying of the stomach. However, you can have some gastrointestinal discomfort as a result of this prolonged digesting process.

Intestinal issues make up the majority of Wegovy’s common side effects, or those that impact over 5% of users, such as:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Abdominal pain
  • Headache
  • Fatigue
  • Indigestion
  • Dizziness
  • Injection site reaction

 

Nausea

According to 44% of Wegovy customers, nausea is one of the most frequent adverse effects. Usually, it happens when the medicine is started or when the dosage is increased. Wegovy frequently causes nausea by slowing down the stomach’s emptying process, which can lead to uncomfortable and full emotions.

As directed by your healthcare practitioner, increase your dosage gradually to help your body acclimate to the nausea that Wegovy causes. You may avoid overfilling your stomach by eating smaller, more frequent meals rather than larger ones.

Another way to lessen nausea causes is to stay away from fatty, spicy, and rich meals.

Nausea can also be successfully reduced by using natural medicines like peppermint or ginger tea. Another way to stay hydrated is to drink little quantities of water throughout the day rather than all at once.

Diarrhea

Thirty percent of Wegovy users report experiencing diarrhea occurrences. This is often transient while your body gets used to the medicine and can range from mild to moderate. Avoid dehydration by drinking electrolyte-containing drinks to keep hydrated. Cutting back on fried, spicy, and high-fat foods can also be beneficial.

Your symptoms may also be lessened by following the BRAT diet, which consists of basic, easily digested meals like bread, rice, bananas, and applesauce.

Vomiting

Some people may throw up, especially if they have extreme nausea. This may occur more frequently with dosage increases or when the medicine is first started. As with controlling nausea, vomiting may be prevented by eating smaller, more frequent meals and avoiding fatty or spicy foods.

Additionally, as your body becomes used to Wegovy, try to minimize any foods or behaviors that make you throw up.

Constipation

Although diarrhea is prevalent, constipation is a side effect that some people may have. Of Wegovy users, 24% experience constipation and it might be brought on by Wegovy’s delayed digestion.

Additionally, some users report drinking less water and feeling stuffed more quickly when using Wegovy, which may exacerbate constipation.

Constipation can be controlled by Increasing fiber intake through whole grains, fruits, and vegetables. It’s also critical to stay hydrated since water improves the effectiveness of fiber.

Regular exercise has the potential to improve digestion as well. Consult your healthcare professional before using mild laxatives or fiber supplements, if needed.

Abdominal Pain

Wegovy’s effects on the gastrointestinal tract may be the source of some users’ complaints of discomfort or pain in the abdomen. This includes upper and lower abdominal pain, soreness, and discomfort.

Take note of your fullness cues, which you may modify on Wegovy, to lessen stomach ache and only eat until you are satisfied.

Acetaminophen and other nonprescription pain relievers are also safe for you to use, but it’s better to check with your provider first.

Headache

It is possible to experience headaches, especially during the early phases of Wegovy therapy. Wegovy may affect the vascular system, which might result in headaches, according to some research.

Since dehydration is a major cause of headaches, make sure you remain hydrated. To avoid blood sugar dips that might cause headaches, avoid missing meals.

Additionally, it is beneficial to get adequate sleep and use relaxation techniques to manage stress. You can use pain relievers that like acetaminophen or ibuprofen if the pain doesn’t go away.

Fatigue

Fatigue is another Wegovy side effect that has been recorded. This might be as a result of the body adapting to the medication’s effects on metabolism and appetite.

Eat a balanced diet to receive all the nutrients you need if you feel exhausted. Aim for 7 to 9 hours of sleep per night since getting enough sleep is crucial.

Regular exercise, even if it’s only mild, can increase vitality. To prevent overdoing it, strike a balance between rest and exercise throughout the day.

Indigestion

Changes in the way your stomach breaks down food might also lead to indigestion or heartburn.

Heartburn can be controlled by avoiding meals that provoke it, such as spicy or fatty foods.

Digestion can be facilitated by eating smaller, more frequent meals. Additionally, it’s crucial to wait at least two to three hours after eating before lying down. Talk with your provider regarding solutions to help if suffering from this condition.

Dizziness

Some Wegovy users have complained of feeling lightheaded. Dizziness can be brought on by eating less, drinking too little water, or losing fluids due to diarrhea or vomiting. Usually transient, this might disappear on its own.

Sit or lie down until the dizziness subsides. It’s critical to stay hydrated since dehydration might make you feel lightheaded. To prevent abrupt reductions in blood pressure, gently stand up or shift positions.

Injection Site Reactions

Some patients may have injection site responses, such redness, swelling, or irritation, since Wegovy is provided via injection.

Rotate injection sites to prevent utilizing the same location again to decrease injection site responses. To reduce irritation, use the right injection techniques. Redness and swelling can also be lessened by applying a cold compress.

Serious Side Effects of Wegovy

Most people experience mild side effects. However, Wegovy may have rare yet serious side effects, which include:

  • Pancreatitis
  • Gallbladder problems
  • Kidney problems
  • Allergic reactions
  • Increased heart rate
  • Depression or suicidal thoughts
  • Thyroid tumors
  • Severe gastrointestinal issues
  • Low blood sugar

 

Pancreatitis

An inflammation of the pancreas, known as pancreatitis, is a dangerous side effect that needs to be treated right away.

Severe stomach discomfort that might spread to your back, nausea, vomiting, fever, and a fast heartbeat are some of the symptoms. If you encounter these symptoms, get medical attention right away.

Gallbladder Problems

Wegovy may raise the risk of gallbladder problems, such as gallstones and gallbladder inflammation (cholecystitis), however these are uncommon.

Severe abdominal discomfort, especially in the center or upper right section of the abdomen, pain radiating to the shoulder or back, nausea, vomiting, and fever are symptoms to be aware of.

Stop taking the drug and speak with your provider if you encounter these side effects.

Kidney Problems

Wegovy has an impact on renal function, which may cause new kidney issues or make worse pre-existing ones.

Shortness of breath, exhaustion, edema in your legs or ankles, and decreased urine production are signs of kidney problems. Maintaining enough hydration, keeping an eye on any changes in urination or edema, and informing your provider of these are all crucial.

Allergic Reactions

Although they are uncommon, Wegovy allergies can range in severity. More severe reactions can include itching, rash, swelling, particularly of the face, lips, tongue, and throat, extreme lightheadedness, and difficulty breathing are some of the symptoms.

A severe allergic response that necessitates prompt emergency medical intervention is anaphylaxis. Stop taking the drug and get medical care right away if you think you may be having an allergic reaction.

Increased Heart Rate

Wegovy may raise heart rate, which might be observable as a pounding or racing heart. A minor rise in heart rate might not be harmful, but a considerable or ongoing increase should be assessed by a healthcare professional. Watch for symptoms such as chest discomfort, dizziness, shortness of breath, and palpitations.

Depression or Suicidal Thoughts

Although it is uncommon, using Wegovy may cause mood swings in certain people, such as sadness or suicidal thoughts. Any changes in behavior, mood, or suicidal thoughts should be closely observed. See a healthcare professional urgently or call 911 if you or someone you know suffers from these symptoms.

Thyroid Tumors

Although it is unknown if this risk also exists in people, wegovy has been linked in animal studies to an elevated risk of thyroid C-cell cancers. A lump or swelling in your neck, trouble swallowing, hoarseness, or shortness of breath are some symptoms to watch out for. For a more thorough assessment, let your doctor know about any of these symptoms.

Additionally, if you have a family history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) or medullary thyroid carcinoma (a kind of thyroid cancer), the FDA advises against using GLP-1 agonists like Wegovy.

Severe Gastrointestinal Issues

Severe gastrointestinal problems might sometimes arise, even if minor ones like nausea and diarrhea are typical. These include dehydration, excruciating stomach discomfort, and ongoing vomiting or diarrhea. Get in touch with your provider if you have severe stomach issues.

Hypoglycemia (Low Blood Sugar)

Low blood sugar can result from Wegovy, especially in those with type 2 diabetes who are simultaneously using blood sugar-lowering medicines.

Hypoglycemia manifests as lightheadedness, perspiration, disorientation, trembling, hunger, and agitation. Talk to your healthcare practitioner about adjusting the amounts of your other diabetic medications if you have diabetes.

 

Is it Normal to Feel Sick After Eating on Wegovy?

Yes, feeling nauseous after eating on Wegovy is a regular occurrence. This drug targets parts of the brain that control hunger and food intake by imitating the GLP-1 hormone. This might cause gastrointestinal adverse effects, including nausea, even though it can be quite successful for losing weight.

Wegovy prolongs feelings of fullness by slowing down the stomach’s emptying. Although this can help cut calories, it can also make you feel nauseous, especially after eating.

An upset stomach might result from food remaining in the stomach for longer than is normal. Furthermore, Wegovy can occasionally result in a mismatch between the amounts of food you consume and how your body processes it, which can produce nausea and vomiting since it affects the brain’s appetite and satiety regions.

Individual differences exist in the frequency and severity of nausea. Some people may experience no nausea. Others may have moderate and controllable nausea, while others may experience more severe symptoms.

When you initially start taking Wegovy or when your dosage is raised, these adverse effects are the most noticeable. Many people experience nausea that either disappears or is easier to control as their digestive system get used to the medicine.

 

How Do You Stop Feeling Sick On Wegovy?

It’s crucial to record all symptoms, no matter how severe, when taking Wegovy in case you need to visit your medical provider. Nonetheless, there are a few tactics that might assist in reducing these adverse effects and enhance your overall pharmacological experience.
Here are some strategies to control and lessen Wegovy-related nausea and vomiting:

  • Gradually increase your dose.
  • Consume small meals frequently.
  • Steer clear of trigger foods.
  • Eat slowly.
  • Increase your fiber intake and stay hydrated.
  • Sample herbal teas, such as peppermint and ginger teas.
  • Try taking Wegovy with or without meals to see which makes you feel less queasy.
  • After eating, remain upright for at least half an hour.
  • To lower the risk of nausea and indigestion, avoid lying down right after eating.
  • Take part in regular exercise.
  • Adhere to a routine and administer your Wegovy shots on the same day every week.
  • Rotate the place of your injection. 

 

Wegovy Side Effects FAQ

What are the most common side effects of Wegovy?

Diarrhea, nausea, vomiting, constipation, headache, stomach discomfort, exhaustion, lightheadedness, indigestion, and injection site responses are among the most frequent adverse effects of Wegovy. As your body becomes used to the drug, these mild to moderate adverse effects will gradually fade away.

How can I reduce nausea while taking Wegovy?

Avoid rich, spicy, and fatty foods and consider eating smaller, more frequent meals to lessen nausea. Drinking water throughout the day and eating items that include peppermint or ginger can also help you stay hydrated. See your healthcare provider for more advice or medicine if your nausea doesn’t go away.

What should I do if I experience severe side effects from Wegovy?

Seek medical help right away if you suffer from severe Wegovy side effects. Talk about your symptoms and any changes to your treatment plan with your healthcare practitioner.

Are there any foods or medications I should avoid while taking Wegovy?

Wegovy is not contraindicated for any particular food or medications, however it is advisable to stay away from foods that exacerbate gastrointestinal side effects, such as fatty or spicy foods.

 

How A-OK Vitality & Wellness Can Help

At A-OK Vitality & Wellness, we recognize that controlling weight loss can be difficult, particularly while coping with Wegovy’s adverse effects. Our weight loss clinic is committed to offering you individualized treatment and all-encompassing assistance so you may comfortably and successfully reach your weight reduction goals.

You begin with a modest dose of Wegovy in our weight reduction program, and as your body adjusts, the dosage is progressively increased. By doing this, the likelihood and intensity of adverse effects are reduced. To guarantee the greatest results, our skilled medical professionals will collaborate closely with you and modify your treatment plan as necessary.

We are aware that not everyone is a good fit for Wegovy. For this reason, we provide a number of pharmaceutical alternatives that are suited to your particular needs. To provide the best and most efficient treatment alternatives, we evaluate your medical history, current health, and weight reduction objectives.

To find out how we can assist you with managing the side effects of Wegovy and examine customized weight reduction alternatives, Contact A-OK Vitality & Wellness today.